Changing the IP address of your mail server is more complicated than just modifying the network card settings. There's a few other places where the address needs to be changed.
dnscache
Change the IP address in /service/dnscache/env/IP, then restart the service (svc -t /service/dnscache).
SMTP
The run scripts for your SMTP service(s) need to be modified to reflect the new IP address you want them to listen on. Depending on which services you've enabled, you might need to edit:
/service/smtp-external/run
/service/smtp-internal/run
/service/smtp-ssl/run
/service/smtp-tls/run
Webmail
The IMAP server setting in your webmail configuration will need to be updated.