Performance Tuning

Disable automatic maintenance
In the Maintenance Settings, disable http://ads.example.com/www/admin/account-settings-maintenance.php, disable Automatically perform maintenance during delivery if scheduled maintenance is not set up and enable maintenance as a cron task:

cd /etc/cron.d
echo '0 * * * * root /usr/local/bin/php -f /var/websites/ads.example.com/htdocs/openx-2.8.7/maintenance/maintenance.php' > openx-maintenance
chmod 644 openx-maintenance
touch /etc/crontab

There's a variety of other ways to configure the cron task.
Disable debug logging
Uncheck the checkbox on

Store Images in a Directory, not the Database
Rather than having the ad files stored within the databse, create a directory to hold them:

cd /var/websites/ads.example.com/htdocs
mkdir ads
chown nobody:nobody ads

In Configuration -> Global Settings -> Banner Storage Settings, enable Allow Webserver Local Banners.
For the storing method, choose Local Directory and specify the Local Directory:

/var/websites/ads.example.com/htdocs/ads

Resources
Performance Tuning Techniques
OpenX Performance Tuning Tips
Openx Handbook Openx Server Optimization And Performance Tuning

Recent Updates

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    php 8.x
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    10.6.7
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    Drop Centos 5/6 stuff